Feverfew (2024)

Bowe WP. Cosmetic benefits of natural ingredients: mushrooms, feverfew, tea and wheat complex. J Drugs Dermatol. 2013;12(9 Suppl):s133-6.

Cady RK, Goldstein J, Nett R, Mitchell R, Beach ME, Browning R. A double-blind placebo-controlled pilot study of sublingual feverfew and ginger (LipiGesic™ M) in the treatment of migraine. Headache. 2011 Jul-Aug;51(7):1078-86. doi: 10.1111/j.1526-4610.2011.01910.x.

Chen CF, Leung AY. Gene response of human monocytic cells for the detection of antimigraine activity of feverfew extracts. Can J Physiol Pharmacol. 2007;85(11):1108-15.

Curry EA 3rd, Murry DJ, Yoder C, et al., Phase I dose escalation trial of feverfew with standardized doses of parthenolide in patients with cancer. Invest New Drugs. 2004;22(3):299-305.

De Weerdt CJ, Bootsma HPR, Hendriks H. Herbal Medicines in migraine prevention. Randomized double-blind placebo controlled crossover trial of a feverfew preparation. Phytomedicine. 1996;3:22-230.

Diener HC, Pfaffenrath V, Schnitker J, Friede M, Henneicke-von Zepelin HH. Efficacy and safety of 6.25 mg t.i.d. feverfew CO2-extract (MIG-99) in migraine prevention -- a randomized, double-blind, multicentre, placebo-controlled study. Cephalalgia. 2005;25(11):1031-41.

Martin K, et al. Parthenolide-depleted Feverfew (Tanacetum parthenium) protects skin from UV irradiation and external aggression. Arch Dermatol Res. 2008;300(2):69-80.

Miller L. Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions. Arch Intern Med. 1998;158(20):2200-2211.

Murphy JJ, Heptinstall S, Mitchell JR. Randomised double-blind placebo-controlled trial of feverfew in migraine prevention. Lancet. 1988;2:189-192.

Palevitch D, Earon G, Carasso R. Feverfew (Tanacetum parthenium) as a prophylactic treatment for migraine: a double-blind controlled study. Phytotherapy Res. 1997;11:508-511.

Pareek A, Suthar M, Rathore GS, Bansal V. Feverfew (Tanacetum parthenium L.): A systematic review. Pharmacogn Rev. 2011 Jan;5(9):103-10. doi: 10.4103/0973-7847.79105.

Pattrick M, Heptinstall S, Doherty M. Feverfew in rheumatoid arthritis: a double-blind, placebo controlled study. Ann Rheum Dis. 1989;48:547-549.

Pfaffenrath V, Diener HC, Fischer M, et al. The efficacy and safety of Tanacetum parthenium (feverfew) in migraine prophylaxis--a double-blind, multicentre, randomized placebo-controlled dose-response study. Cephalalgia. 2002;22(7):523-532.

Pittler MH, Vogler BK, Ernst E. Feverfew for preventing migraine. [Review] Cochrane Database Syst Rev. 2000;(3):CD002286.

Rodriguez KJ, Wong HK, Oddos T, Southall M, Frei B, Kaur S. A purified feverfew extract protects from oxidative damage by inducing DNA repair in skin cells via a P13-kinase-dependent Nrf2/ARE pathway. J Dermatol Sci. 2013;72(3):304-10.

Schiapparelli P, Allais G, Castagnoli Gabellari I, Rolando S, Terzi MG, Benedetto C. Non-pharmacological approach to migraine prophylaxis: part II. Neurol Sci. 2010 Jun;31 Suppl 1:S137-9. Review.

Shrivastava R, Pechadre JC, John GW. Tanacetum parthenium and Salix alba (Mig-RL) combination in migraine prophylaxis: a prospective, open-label study. Clin Drug Investig. 2006;26(5):287-96.

Silberstein SD. Preventive treatment of headaches. Curr Opin Neurol. 2005;18(3):289-92.

Won YK, Ong CN, Shi X, Shen HM. Chemopreventive activity of parthenolide against UVB-induced skin cancer and its mechanisms. Carcinogenesis. 2004;25(8):1449-58.

Wu C, Chen F, Rushing JW, Wang X, Kim HJ, Huang G, Haley-Zitlin V, He G. Antiproliferative activities of parthenolide and golden feverfew extract against three human cancer cell lines. J Med Food. 2006;9(1):55-61.

Yao M, Ritchie HE, Brown-Woodman. A reproductive screening test of feverfew: is a full reproductive study warranted? Reprod Toxicol. 2006;22(4):688-93.

Zhang S, Lin ZN, Yang CF, Shi X, Ong CN, Shen HM. Suppressed NF-kappaB and sustained JNK activation contribute to the sensitization effect of parthenolide to TNF-alpha-induced apoptosis in human cancer cells. Carcinogenesis. 2004;25(11):2191-9.

FAQs

Does feverfew actually work? ›

Parthenolide, as well as other chemicals in feverfew, might help decrease migraine headaches. People most commonly use feverfew for migraine headaches. People also use feverfew for itching, tension headache, and many other conditions, but there is no good scientific evidence to support these uses.

See Details ›

Is it safe to take feverfew every day? ›

Several human studies have used feverfew to prevent and treat migraines. Overall, these studies suggest that taking dried leaf capsules of feverfew every day may reduce the number of migraines in people who have chronic migraines.

Show Me More ›

What is the best form of feverfew for migraines? ›

However, studies find that taking 100 to 300 milligrams (mg) of a feverfew supplement containing 0.2% to 0.4% parthenolide between one and four times daily may treat migraine headaches ( 1 ). Feverfew is also available as fluid extracts or tinctures, which are typically used to relieve arthritis.

Learn More ›

What does feverfew do to the body? ›

No serious side effects have been reported from feverfew use. Side effects can include nausea, digestive problems, and bloating; if the fresh leaves are chewed, sores and irritation of the mouth may occur. People who are sensitive to ragweed and related plants may experience allergic reactions to feverfew.

Discover More ›

How long does it take for feverfew to kick in? ›

Feverfew may ease nausea and vomiting due to migraines. It may take a month or longer for it to work.

Learn More ›

Does feverfew help with anxiety? ›

A 2017 animal study found that feverfew had antidepressant and anti-anxiety effects on mice. The researchers believed the effects were due to how feverfew interacted with the GABAergic system. This system is a network of brain neurons that inhibit nerve transmission and slow the brain to reduce anxiety.

Explore More ›

Does feverfew block serotonin? ›

Feverfew is believed to have painkilling and anti-inflammatory properties. It's been suggested that it reduces the release of an inflammatory substance, serotonin, from your blood cells and slows down the production of a chemical transmitter in your body called histamine.

Tell Me More ›

Is feverfew a natural antihistamine? ›

The leaves are used as a natural herbal supplement. Tanacetum parthenium contains parthenolide, which works on serotonin receptors in the brain, giving relief from migraine headaches. Tanacetum parthenium is also believed to have anti-inflammatory, pain relieving, and anti-histamine effects.

Get More Info Here ›

Does feverfew cause weight gain? ›

Side effects might include upset stomach, heartburn, diarrhea, constipation, bloating, flatulence, nausea, and vomiting. Other reported side effects include nervousness, dizziness, headache, trouble sleeping, joint stiffness, tiredness, menstrual changes, rash, pounding heart, and weight gain.

Tell Me More ›

What is the 3 drug co*cktail for migraine? ›

To make an at-home migraine co*cktail that resembles OTC products, people can take: 250 mg of aspirin. 250 mg of acetaminophen. 65 mg of caffeine, which is the amount in approximately 5.5 ounces of brewed coffee.

View Details ›

What is the strongest migraine pain relief? ›

What else did the study show about migraine pain relievers?

Triptans scored five to six times more helpful than ibuprofen. The highest ranked drug, eletriptan, helped 78% of the time. ...
Ergots were rated as three times more helpful than ibuprofen.
Anti-emetics were 2.5 times as helpful as ibuprofen.

Feb 5, 2024

What is the instant relief for migraine? ›

Apply hot or cold compresses to your head or neck. Ice packs have a numbing effect, which may dull the pain. Hot packs and heating pads can relax tense muscles. Warm showers or baths may have a similar effect.

Know More ›

Can you take feverfew long term? ›

People have not reported serious side effects of feverfew. Researchers have used it safely with people in studies lasting up to four months. No one knows whether it is safe if you use it longer than that.